Autologous Peripheral Blood Mononuclear Cells as Treatment in Refractory Acute Respiratory Distress Syndrome

Background: Acute respiratory distress syndrome (ARDS) is a devastating disorder. Despite enormous efforts in clinical research, effective treatment options are lacking, and mortality rates remain unacceptably high. Objectives: A male patient with severe ARDS showed no clinical improvement with conventional therapies. Hence, an emergent experimental intervention was performed. Methods: We perReceived: April 30, 2015 Accepted after revision: October 12, 2015 Published online: November 28, 2015 Paolo Macchiarini, MD, PhD Division of Ear, Nose and Throat (CLINTEC), Advanced Center for Translational Regenerative Medicine (ACTREM), Karolinska Institutet Hälsovägen 7, Huddinge, SE–141 86 Stockholm (Sweden) E-Mail paolo.macchiarini @ ki.se © 2015 S. Karger AG, Basel 0025–7931/15/0906–0481$39.50/0 www.karger.com/res P. Jungebluth and B. Holzgraefe contributed equally to this work. D ow nl oa de d by : 54 .7 0. 40 .1 1 11 /9 /2 01 7 7: 55 :4 5 P M